This study explores the impact of integrating the 5E Learning Cycle and WebQuest as innovative instructional strategies to improve genetics education among secondary school students in Rivers State, Nigeria. Genetics, a fundamental component of the biology curriculum, is often perceived as abstract and difficult by students, leading to poor comprehension and performance. Traditional teaching methods, largely teacher-centered, have not effectively addressed these challenges. Supports active student participation and conceptual understanding. When combined with WebQuest, a technology-driven, inquiry-oriented learning strategy that utilizes web resources for guided exploration, the approach promises a more engaging and effective learning experience.

The study adopted a quasi-experimental design involving selected senior secondary schools in Rivers State. Participants were divided into experimental and control groups. The experimental group received instruction using the 5E Learning Cycle and WebQuest, while the control group was taught using traditional lecture methods. instruments on genetics concepts were administered to evaluate knowledge gains.