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VOL. 2, ISSUE 2 (2026)
Comprehensive obesity management: A Review of GLP-1 receptor agonists and dual incretin therapies
Authors
Roja H R, Priya Sapui, Dipmala Das, Souvik Tewari
Abstract
Obesity is a chronic,
relapsing metabolic disease associated with cardiovascular disease, type 2
diabetes mellitus, non-alcoholic fatty liver disease, chronic kidney disease,
obstructive sleep apnea, osteoarthritis, infertility, and several cancers. Traditional
management strategies involving calorie restriction, physical activity, behavioural
therapy, and bariatric surgery have demonstrated variable long-term success,
emphasizing the need for more effective pharmacological interventions. Over the
past decade, glucagon-like peptide-1 receptor agonists (GLP-1RAs) have
revolutionized obesity treatment by producing unprecedented weight reduction
while simultaneously improving metabolic health. More recently, dual incretin
agonists, particularly glucose-dependent insulinotropic polypeptide (GIP)/GLP-1
receptor agonists such as tirzepatide, have demonstrated even greater efficacy.
Emerging multi-receptor agonists targeting GLP-1, GIP, and glucagon receptors
promise additional metabolic benefits. Beyond weight reduction, these agents
improve insulin sensitivity, reduce cardiovascular risk, attenuate hepatic
steatosis, preserve renal function, decrease systemic inflammation, improve
reproductive health, and potentially influence neurodegenerative diseases. This
review summarizes current evidence regarding the mechanisms of action, clinical
efficacy, cardiometabolic benefits, safety profile, limitations, and future
directions of GLP-1 receptor agonists and dual agonists in comprehensive
obesity management. Current evidence supports a paradigm shift from
weight-centered treatment toward holistic metabolic disease management.
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Pages:13-20
How to cite this article:
Roja H R, Priya Sapui, Dipmala Das, Souvik Tewari "Comprehensive obesity management: A Review of GLP-1 receptor agonists and dual incretin therapies". World Journal of Academic Research
, Vol 2, Issue 2, 2026, Pages 13-20
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